FORMULASI DAN UJI SENSITIVITAS SEDIAAN GEL DARI ANTIBIOTIK DOKSISIKLIN DAN TETRASIKLIN TERHADAP BAKTERI Propianibacterium acne

SITUMORANG, UCOK SANGAP (2019) FORMULASI DAN UJI SENSITIVITAS SEDIAAN GEL DARI ANTIBIOTIK DOKSISIKLIN DAN TETRASIKLIN TERHADAP BAKTERI Propianibacterium acne. Undergraduate thesis, Institut Kesehatan Helvetia.

Text UCOK SANGAP SITUMORANG (1701012158).pdf Download (4MB)

Abstract

Background: Acne is a chronic inflammatory disease of the pilosebaceous unit caused by the bacterium Propionibacterium acnes. Anti-acne preparations were chosen in gel preparations because they have the advantage of being non-sticky and containing no oil and volatile properties. Objective: The purpose of this study was to determine whether doxycycline and tetracycline can be formulated as anti-acne gel and to find out a comparison of the dosage of doxycycline, tetracycline and Mediklin® gel against Propionibacterium acne bacteria. Method: This study of research was an experimental parametric method including preparation of gel preparations (concentrations of tetracycline and doxycycline 1 mg, 2 mg, and 4 mg), evaluation of formulas which include: evaluating the stability of preparations, and testing the antibacterial activity of anti-acne gel preparations with comparative gel (Mediklin®) against Propionibacterium acne bacteria (ATCC 6919) by Agar Diffusion method. The study was conducted at the Microbiology Laboratory, Faculty of Pharmacy, University of North Sumatra. Based on Organoleptic variable, the results showed in cold temperatures that the shape, odour and colour did not change experienced, otherwise in room temperature it was experienced, but for the Mediklin® gel did not change. Result: The test results of antibacterial activity of tetracycline concentration of 1 mg, against propionibacterium acnes bacteria obtained 24.03 mm, doxycycline concentration of 1 mg, against propionibacterium acne bacteria obtained 24.37 mm, the concentration of Mediklin® gel obtained 1% was 17.94%. Conclusion: Tetracycline and doxycycline have very strong inhibition.

Item Type:	Doktoral (Undergraduate)
Additional Information:	Tetrasiklin, Doksisiklin, sediaan gel, propionibacterium acnes
Subjects:	Fakultas Farmasi dan Kesehatan > Farmasi Fakultas Farmasi dan Kesehatan > Farmasi > Formularium
Divisions:	Fakultas Farmasi dan Kesehatan > S1 Farmasi
Depositing User:	Ucok Sangap Situmorang
Date Deposited:	27 Feb 2020 02:29
Last Modified:	27 Feb 2020 02:29
URI:	http://repository.helvetia.ac.id/id/eprint/2363

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