A novel composite membrane pectin from Cyclea Barbata Miers blend with chitosan for accelerated wound healing

Sari, Mayang and Tamrin, - and Kaban, Jamaran and Alfian, Zul (2021) A novel composite membrane pectin from Cyclea Barbata Miers blend with chitosan for accelerated wound healing. Polymer Testing, 99. pp. 1-6. ISSN 0142-9418

Text 9. Q1 MEI 2021 (1).pdf Download (2MB)

Abstract

In this work, pectin derived from Cyclea Barbata Miers (CBM) was successfully blended with chitosan as a novel
membrane and the physico-chemical analysis was investigated. Based on SEM analysis revealed that the chitosan/pectin blended membrane showed a rough surface texture compared to pristine chitosan with smooth and
uniform membran. In addition, fourier-transform infrared spectroscopy (FTIR) analysis indicates that chitosan
and pectin were successfully crosslinked, meanwhile x-ray diffraction (XRD) analysis found that pectin extracted
from CBM exhibited crystalline structure. Thermal analysis based on thermogravimetric analysis (TGA) suggesting that chitosan/pectin blend membrane exhibited significant improvement in the thermal stability with
residual mass of 54% at 360 ◦C. Furthermore, swelling degree, water vapor transmission rate (WVTR) and
porosity of the chitosan/pectin blend membrane were 266%, 9.68 g/m2
h, and 64%, respectively. Most importantly, in-vivo results indicated that the prepared membrane of chitosan/pectin immobilized with Musa Paradisiaca Linn (MPL) group had better wound closure with better wound reduction percentage than the gauzetreated wound (the control group). This finding revealed that the chitosan/pectin blend membrane could
paves the way for future biomedical wound dressing application.

Item Type:	Article
Uncontrolled Keywords:	Chitosan Pectin Cyclea Barbata Miers Membrane Wound healing
Subjects:	Fakultas Kesehatan Masyarakat > Kesehatan Masyarakat
Divisions:	Fakultas Kesehatan Masyarakat
Depositing User:	Pustakawan Mr. Pustaka Helvetia
Date Deposited:	26 Oct 2023 09:29
Last Modified:	26 Oct 2023 09:29
URI:	http://repository.helvetia.ac.id/id/eprint/5556

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