ANTIHYPERGLYCEMIC ACTIVITIES ETHANOL EXTRACT OF Musa paradisiaca L STEMS AND DETERMINATION OF ITS ACTIVE COMPONENTS USING GC-MS

Sari, Mayang and Tamrin, - and Kaban, Jamaran and Alfian, Zul (2020) ANTIHYPERGLYCEMIC ACTIVITIES ETHANOL EXTRACT OF Musa paradisiaca L STEMS AND DETERMINATION OF ITS ACTIVE COMPONENTS USING GC-MS. Rasayan J. Chem, 13 (4). pp. 2508-2514. ISSN 0974-1496

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Abstract

Various research on antihyperglycemic is continuously performed due to the fact every year the charge of
diabetes patients increases. This study aims to find natural potentials that can be developed as an antihyperglycemic
because existing synthetic drugs give unfavorable effects if used continuously. In this study, the natural potency of
Musa Paradisiaca L was developed as an anti-hyperglycemic agent with the hope that its use would not cause a
prolonged effect. The extract of ethanol’s Musa Paradisiaca L stem (EEMP) obtained by maceration was pretested
by phytochemical screening. And obtained the presence of secondary metabolites, namely: Terpenoids, steroids, and
saponins. Testing with GC-MS was also carried out to determine the active compound in ethanol extract which has
potential as anti-hyperglycemia. The chromatogram results showed that the active compounds detected were: lupeol,
stigmasterol, Cyclolanostan, and obtusifoliol. Previous studies of these components were able to lower blood sugar
levels. The antihyperglycemic test was carried out in vivo on alloxan-induced mice. The treatment of diabetic mice
was divided into 5 groups, namely: positive control, standard treatment, and treatment of extracts (100, 200, and 300
mg/kg BW) was given orally. The progression of decreasing effect of extract and glibenclamide at the 8th day limit
after alloxan induction. The study showed that there were not have significant differences between treatment EECL
and glibenclamide. The hyperglycemic test results clearly show that the ethanol extract of Musa paradisiaca L stem
has the potential in antihyperglycemic treatment.

Item Type:	Article
Uncontrolled Keywords:	Musa.Paradisiaca L, GC-MS, Anti-hyperglycemic, Terpenoids, Saponin, Stigmasterol, Steroids
Subjects:	Fakultas Kesehatan Masyarakat > Kesehatan Masyarakat
Divisions:	Fakultas Kesehatan Masyarakat
Depositing User:	Pustakawan Mr. Pustaka Helvetia
Date Deposited:	26 Oct 2023 09:10
Last Modified:	26 Oct 2023 09:10
URI:	http://repository.helvetia.ac.id/id/eprint/5553

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